© The Author(s), 2022. Published by Cambridge University Press on behalf of The Royal Society of Edinburgh.We deal with analytic three-dimensional symmetric systems whose origin is a Hopf-zero singularity. Once it is not completely analytically integrable, we provide criteria on the existence of at least one functionally independent analytic first integral. In the generic case, we characterize the analytic partially integrable systems by using orbitally equivalent normal forms. We also solve the problem through the existence of a class of formal inverse Jacobi multiplier of the system.